Synthesis and Antihypoxic Properties of New Derivatives 1,4-Benzodioxanil-1,3,4-oxadiazole

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Abstract

Condensation of previously synthesized 1,4-benzodioxane-2-carboxylic acid hydrazide with chloranhydrides of various arylcycloalkane-, as well as aerylterrahydropyrancarboxylic acids substituted in the aromatic ring, gave N,N′-diacyl-substituted hydrazines, which are cyclized under the action of phosphorus oxychloride to the corresponding 1,3,4-oxadiazolebenzodioxanes. The antihypoxic properties of the synthesized compounds were studied.

About the authors

S. O Vartanyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID iD: 0000-0003-4582-7629
Yerevan, Armenia

A. S Avakyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: avaga@mail.ru
ORCID iD: 0000-0002-7148-3666
Yerevan, Armenia

A. B Sargsyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID iD: 0000-0001-7115-9164
Yerevan, Armenia

G. A Panosyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Yerevan, Armenia

S. A Arutyunyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID iD: 0000-0003-3748-6975
Yerevan, Armenia

G. V Gasparyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID iD: 0000-0002-8555-3733
Yerevan, Armenia

A. A Agekyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID iD: 0000-0001-6151-4951
Yerevan, Armenia

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