Synthesis and Antihypoxic Properties of New Derivatives 1,4-Benzodioxanil-1,3,4-oxadiazole

Capa

Citar

Texto integral

Acesso aberto Acesso aberto
Acesso é fechado Acesso está concedido
Acesso é fechado Acesso é pago ou somente para assinantes

Resumo

Condensation of previously synthesized 1,4-benzodioxane-2-carboxylic acid hydrazide with chloranhydrides of various arylcycloalkane-, as well as aerylterrahydropyrancarboxylic acids substituted in the aromatic ring, gave N,N′-diacyl-substituted hydrazines, which are cyclized under the action of phosphorus oxychloride to the corresponding 1,3,4-oxadiazolebenzodioxanes. The antihypoxic properties of the synthesized compounds were studied.

Sobre autores

S. Vartanyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID ID: 0000-0003-4582-7629
Yerevan, Armenia

A. Avakyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: avaga@mail.ru
ORCID ID: 0000-0002-7148-3666
Yerevan, Armenia

A. Sargsyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID ID: 0000-0001-7115-9164
Yerevan, Armenia

G. Panosyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Yerevan, Armenia

S. Arutyunyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID ID: 0000-0003-3748-6975
Yerevan, Armenia

G. Gasparyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID ID: 0000-0002-8555-3733
Yerevan, Armenia

A. Agekyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

ORCID ID: 0000-0001-6151-4951
Yerevan, Armenia

Bibliografia

  1. The use of stems in the selection of International Non-prietary Names (INN) for pharmaceutical substances WHO, 2018.
  2. Siwach A., Verma P.K., BMC Chem., 2020, 14, 70. doi: 10.1186/s13065-020-00721-2
  3. Vaidya A., Pathak D., Shah K., Chem. Biol. Drug Des., 2021, 97 (3), 572–591. doi: 10.1111/cbdd.13795
  4. Vaghani H., Patel Sh., Patel S. Int. J. Pharm. Sci. Res., 2021, 13, 5292–5299. doi: 10.13040/IJPSR.0975-8232.12(10).5292-99
  5. Авакян А.С., Вартанян С.О., Саргсян А.Б., Маркарян Э.А. ЖОрХ, 2014, 50 (3), 445–449. doi: 10.1134/S1070428014030233
  6. Авакян А.С., Вартанян С.О., Саргсян А.Б., Агекян А.А., Паносян Г.А., Пароннкин Р.В., Степанян Г.М., Мурдлан Р.Е. ЖОрХ, 2020, 56 (3), 373–378. doi: 10.1134/S1070428020030033
  7. Мнджоян А.Л., Татевосян Г.Т. ДАН Арм. ССР, Хим. науки, 1958, 17 (2), 93–97.
  8. Агекян А.А., Мкрян Г.Г., Цатинян А.С., Гаспарян Г.В. ЖОХ, 2019, 89 (5), 812–816. doi: 10.1134/S107036321905027X
  9. Коо І., Avakian S., Martin G.J., J. Am. Chem. Soc., 1955, 77, 5373.
  10. Ширинян Э.А., Арутонян С.А., Гукасян Т.Г. Вестник МАНЭБ, 2003, 8, 132–134.

Arquivos suplementares

Arquivos suplementares
Ação
1. JATS XML
Baixar

Declaração de direitos autorais © Russian Academy of Sciences, 2025