Hepatoprotective efficacy of the use of oxymethyl uracil in various experimental models

Introduction. The formation of toxic liver damage is carried out with the participation of various mechanisms of pathological processes. Chemicals, drugs and alcohol play a significant role. Timely and correct selection of correction drugs will help reduce the risk of toxic organ damage.

The aim of the study is a comparative assessment of the hepatoprotective activity of oxymethyluracil in the early stages of exposure to various toxic agents.

Materials and methods. The studies were carried out on male outbred white rats with a single injection of hepatotoxicants (carbon tetrachloride, paracetamol, ethanol) and a correction drug — oxymethyl uracil — followed by the study of biochemical parameters 1 and 3 days after the introduction of the chemical agent.

Results. As a result of the studies carried out, it was found that specific metabolic changes are noted already one day after exposure to toxicants in the body of animals. Correction of tetrachloromethane and paracetamol intoxication with oxymethyl uracil leads to the normalization of the functional state of hepatocytes.

Conclusion. Oxymethyl uracil exhibits hepatoprotective properties already in the early stages of acute toxic liver damage (1-3 days), being most effective in tetrachloromethane and paracetamol intoxication.

Contribution:
Khusnutdinova N.Yu. — concept and design of the study, writing the text;
Repina E.F. — concept and design of the study, collection of material and data processing, editing;
Karimov D.O., Yakupova T.G., Smolyankin D.A. — a collection of material and data processing;
Timasheva G.V. — a collection of material and data processing, statistical processing;
Mustafin A.G. — oxymethyl uracil synthesis.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manuscript final version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The work was carried out at the expense of subsidies to implement a state task within the framework of the sectoral research program of Rospotrebnadzor “Hygienic scientific substantiation of minimizing risks to the health of the population of Russia” for 2016-2020 on topic 3.5, State no. registration AAAA-A16-116022610045-4.

Conclusion of the bioethical commission: the study was approved by the bioethical commission of the “Ufa Research Institute of Occupational Health and Human Ecology”, carried out per the European Convention for the Protection of Vertebrate Animals Used for Experiments or Other Scientific Purposes (ETS N 123), the directive of the European Parliament and the Council of the European Union 2010/63/EU of 22.09.2010 on the protection of animals used for scientific purposes.

Received: June 02, 2021 / Accepted: September 28, 2021 / Published: November 30, 2021