Short-term perinatal hypoxia does not affect the functioning of skeletal muscle arteries in adult rats

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Resumo

Perinatal hypoxia is one of the most common pathologies in early ontogenesis, which can have a programming effect on the functioning of the vascular system. The latter has been shown for the pulmonary arteries, as well as in several studies on systemic arteries. However, there are no data on the delayed effect of perinatal hypoxia on the functioning of the hemodynamically important vascular region of skeletal muscles. In this regard, the aim of this work was to study the delayed effects of a short-term normobaric hypoxia in early ontogenesis on the functioning of skeletal muscle arteries in adulthood. In this work, normobaric hypoxia (8% O2) was applied for 2 hours in 2-day-old male rats, after which they were raised to adulthood (11-12 weeks) and the functional activity of the sural arteries and the level of systolic blood pressure were assessed. Contractile responses of the sural arteries to an α1-adrenoceptor agonist, endothelium-dependent relaxation responses of arteries to acetylcholine and endothelium-independent relaxation responses to an NO-donor did not differ between the Hypoxia and Control groups. The anticontractile effects of NO and Ca2+-activated potassium channels of large conductance, as well as the procontractile effect of Rho-kinase in arteries were not changed in rats that underwent perinatal hypoxia. Systolic blood pressure levels did not differ between the groups. Thus, according to the results presented in this work, short-term normobaric perinatal hypoxia does not lead to delayed changes in the regulation of sural artery tone and blood pressure in rats in adulthood.

Sobre autores

A. Shvetsova

M.V. Lomonosov Moscow State University

Москва, Россия

S. Simonenko

M.V. Lomonosov Moscow State University

Москва, Россия

I. Kabiolsky

M.V. Lomonosov Moscow State University

Москва, Россия

D. Gaynullina

M.V. Lomonosov Moscow State University

Email: Dina.Gaynullina@gmail.com
Москва, Россия

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