Registration of the penetration of enzymatically modified nanocomposites containing maghemite nanoparticles through lipid membranes

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Resumo

A visual registration of the penetration of enzymatically modified nanocomposites containing maghemite nanoparticles through planar model bilayer asolectin membranes was conducted. Transmembrane current traces were obtained at the moment the nanocomposites passed through the membrane. Transmembrane current spikes were detected, arising during the translocation of nanostructures through the membrane. The measured transmembrane current magnitude allowed estimation of the size of the transmembrane pore to be approximately 10 nm. This pore size closely matched the average diameter of the maghemite nanoparticles comprising the original nanocomposite.

Sobre autores

V. Cherepenin

V.A. Kotelnikov Institute of Radioengineering and Electronics, Russian Academy of Sciences

Mokhovaya Str., 11, bldg. 7, Moscow, 125009 Russian Federation

E. Efimova

Sechenov First Moscow State Medical University of the Ministry of Health of Russia

Trubetskaya Str., 8, bldg. 2, Moscow, 119048 Russian Federation

M. Grigorieva

Sechenov First Moscow State Medical University of the Ministry of Health of Russia

Trubetskaya Str., 8, bldg. 2, Moscow, 119048 Russian Federation

A. Kuandykova

Sechenov First Moscow State Medical University of the Ministry of Health of Russia

Trubetskaya Str., 8, bldg. 2, Moscow, 119048 Russian Federation

V. Spiridonov

Faculty of Chemistry, Lomonosov Moscow State University

Leninskie gory, 1, bldg. 3, Moscow, 119992 Russian Federation

I. Taranov

V.A. Kotelnikov Institute of Radioengineering and Electronics, Russian Academy of Sciences

Email: ivt@cplire.ru
Mokhovaya Str., 11, bldg. 7, Moscow, 125009 Russian Federation

G. Khomutov

V.A. Kotelnikov Institute of Radioengineering and Electronics, Russian Academy of Sciences; Faculty of Physics, Lomonosov Moscow State University

Mokhovaya Str., 11, bldg. 7, Moscow, 125009 Russian Federation; Leninskie gory, 1, bldg. 2, Moscow, 119992 Russian Federation

E. Borisova

Sechenov First Moscow State Medical University of the Ministry of Health of Russia

Trubetskaya Str., 8, bldg. 2, Moscow, 119048 Russian Federation

K. Kalinycheva

Sechenov First Moscow State Medical University of the Ministry of Health of Russia

Trubetskaya Str., 8, bldg. 2, Moscow, 119048 Russian Federation

K. Svinina

Sechenov First Moscow State Medical University of the Ministry of Health of Russia

Trubetskaya Str., 8, bldg. 2, Moscow, 119048 Russian Federation

A. Anosov

V.A. Kotelnikov Institute of Radioengineering and Electronics, Russian Academy of Sciences; Sechenov First Moscow State Medical University of the Ministry of Health of Russia

Mokhovaya Str., 11, bldg. 7, Moscow, 125009 Russian Federation; Trubetskaya Str., 8, bldg. 2, Moscow, 119048 Russian Federation

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