Стимул-чувствительные системы для доставки лекарств на основе бислойных липидных везикул: новые тенденции

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Аннотация

Разработка новых эффективных способов борьбы с тяжелыми заболеваниями, среди которых особое место занимают онкологические и инфекционные, остается актуальной задачей биомедицины и биотехнологии. В настоящее время усилия ученых сосредоточены на поисках лекарственных систем, обеспечивающих высокую эффективность лечения при минимальном воздействии на организм. Развитие этого направления привело к созданию стимул-чувствительных липосом, которые могут высвобождать инкапсулированное лекарство в ответ на определенный стимул: температуру, pH, электромагнитное поле, свет и др. Под воздействием стимула липидные бислойные везикулы изменяют структуру, размер, поверхностный заряд или фазовое состояние, что приводит к контролируемому высвобождению лекарственного препарата в определенном месте в организме, что позволяет добиться более точной и эффективной доставки. В данном обзоре обсуждаются современные тенденции в разработке стимул-чувствительных систем на основе липосом для контролируемой доставки биологически активных веществ.

Об авторах

А. А. Ефимова

Московский государственный университет имени М.В. Ломоносова,
химический факультет

Email: ephimova@genebee.msu.su
Россия, 119991, Москва, Ленинские горы, 1, стр. 3

А. В. Сыбачин

Московский государственный университет имени М.В. Ломоносова,
химический факультет

Автор, ответственный за переписку.
Email: ephimova@genebee.msu.su
Россия, 119991, Москва, Ленинские горы, 1, стр. 3

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