Significance of blood indices for detecting disadaptation in workers in the Far North

Introduction. In the conditions of the Far North (FN), it is relevant to identify disadaptation among workers.

Goal was to assess the significance of blood parameters in the diagnosis of disadaptive changes in the body in those working under FN conditions

Materials and methods. In the summer, total cholesterol, low- and high-density lipoproteins, triglycerides, vitamins (B₉, B₁₂, D), minerals (K, Na, Ca total and ionized, P, Mg, Fe), C-reactive protein, the mineral composition of drinking water was studied.

Results. Signs of anemia confirm a reduced level of cobalamin (100.7±5.2 and 101.4±3.7 pmol/L, p=0.921), B₉ deficiency (86.3% and 93.3% (p=0, 696), low iron levels in 27.3% and 53.3%. Symptoms of hypotonic overhydration are determined by the consumption of low-mineralized drinking water from melted snow. The duration of work led to the development of triglyceridemia (in 50.0% and 60.0%), hypercholesterolemia (for total cholesterol in 90.0% and 93.3%, for low-density lipoproteins – in 90.9% and 73.3%). Elevated high-density lipoproteins among the first group in 72.7%, the second – in 36.7%, causing blood atherogenicity in 40.9% and in 80.0%, C-reactive protein (high in 13.6% and 66.7%) indicated to an increase in the risk of cardiovascular diseases. There were steepened vitamin D deficiency (insufficiency in 71.4% and 53.3%, deficiency in 28.6% and 46.7%), mineral imbalance (K in 9.1% and 20.0%, Ca ionized in 18.2% and 26.7%, Fe – in 9.1% and 20.0%).

Limitations. Blood indices in male military personnel with different lengths of stay in the Arctic, were studied in the summer.

Conclusion. It is necessary to determine high and low density lipoproteins, C-reactive protein, vitamins B₁₂, B₉ and D, minerals (potassium, sodium, ionized calcium and total calcium, magnesium, phosphorus, iron) regardless of age and work experience in the field.

Compliance with ethical standards. The work was carried out in accordance with the conclusion of the Ethics Committee of the Volga Research Medical University of the Ministry of Health of Russia, protocol No. 4 dated March 14, 2022. Patient consent. Each participant of the study (or his/her legal representative) gave informed voluntary written consent to participate in the study and publish personal medical information in an impersonal form in the journal “Gigiena i Sanitariya (Hygiene and Sanitation, Russian journal)”.

Conribuiton:
Rakhmanov R.S. – concept and design of the study, writing the text, responsibility for the integrity of all parts of the article;
Bogomolova E.S. – editing, approval of the final version of the article;
Razgulin S.A. – collection of literature data, participation in the interpretation of results, preparation of the text;
Narutdinov D.A. – collection, systematization of primary material;
Nepryakhin D.V. – statistical processing of the material.
All authors are responsible for the integrity of all parts of the manuscript and approval of the manusfinal version.

Conflict of interest. The authors declare no conflict of interest.

Acknowledgement. The study had no sponsorship. The work was carried out in accordance with the scientific work plan of the Volga Research Medical University and the thesis research plan by D.A. Narutdinov.

Received: June 3, 2024 / Revised: June 18, 2024 / Accepted: October 2, 2024 / Published: March 7, 2025