Recyclization of Pyrimidinium Salt – A Method for the Synthesis of Derivatives of Nitrogen-Containing Heterocycles

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Abstract

By recyclization of 1,4,6-trimethyl-2-ethoxycarbonylmethylpyrimidinium iodide under the action of ethylhydrazine and 4,6-dimethylpyrimidinyl-2-acetic acid hydrazide, 1-ethyl-3-ethoxycarbonylmethyl-5-methyl-1,2,4-triazole and 5,7-dimethyl-3-ethoxycarbonyl-2-(4',6'-dimethyl-yrimidinyl-2')methylpyrazolol[1,5]-alpyrimidine were synthesized, respectively. Alkylation of 1-ethyl-3-ethoxycarbonylmethyl-5-methyl-1,2,4-triazole with various alkyl iodides yielded the corresponding N-alkyltriazolium salts, and reactions of triazolylacetic acid esters yielded their hydrazides. Based on the nuclear Overhauser effect (NOE), it was clearly demonstrated that alkylation occurs at the N-4 nitrogen atom of the triazole ring.

About the authors

G. G. Danagulyan

Russian-Armenian University; The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Email: gdanag@email.com
Yerevan, Armenia; Yerevan, Armenia

L. S. Khachatryan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, Armenia

A. G. Danagulyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, Armenia

M. Yu. Dangyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, Armenia

G. A. Panosyan

The Scientific Technological Center of Organic and Pharmaceutical Chemistry NAS RA

Yerevan, Armenia

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