Possible pathways and mechanisms of weak alternating magnetic fields influence on cognitive functions in drosophila melanogaster

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Today, in an increasingly complex technogenic situation, the study of the effect of alternating magnetic fields (AMF) on biological objects is of particular relevance. The most sensitive to the action of magnetic fields is the nervous system. Using models on Drosophila melanogaster with different content of cryptochrome (CRY) (universal photo- and magnetosensor) in the test of conditional reflex suppression of courtship, the ways and mechanisms of the effect of weak AMF on memory and cognitive functions were studied. As a result of the study, a persistent repetitive effect of changing the behavior of Drosophila was found. It has been shown that in the light, a weak AMF stimulates the formation of medium-term memory in a mutant by the CG1848 gene for LIM kinase 1 agnts3, which is characterized by a violation of the learning processes and the formation of a memorable trace both under normal conditions and when exposed to a weak AMF in the darkness. CRY is the main target of exposure to weak AMF, since data have been obtained on the differential effect of light and dark on the formation of medium-term memory. The role of AMF in cognitive processes was revealed. The participation of CRY and AMF in the processes of memory formation will allow developing effective methods of non-invasive therapy of neuropathologies.

作者简介

A. Medvedeva

Pavlov Institute of Physiology of the Russian Academy of Sciences

St. Petersburg, Russia

B. Shchegolev

Pavlov Institute of Physiology of the Russian Academy of Sciences

St. Petersburg, Russia

S. Surma

Pavlov Institute of Physiology of the Russian Academy of Sciences

St. Petersburg, Russia

E. Tokmacheva

Pavlov Institute of Physiology of the Russian Academy of Sciences

St. Petersburg, Russia

E. Nikitina

Pavlov Institute of Physiology of the Russian Academy of Sciences; Herzen State Pedagogical University of Russia

Email: 21074@mail.ru
St. Petersburg, Russia; St. Petersburg, Russia

E. Savvateeva-Popova

Pavlov Institute of Physiology of the Russian Academy of Sciences

St. Petersburg, Russia

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